Source : Whole Foods Market
1. Sucralose is an artificial substance that is not found in nature, like aspartame and hydrogenated fats. Although supporters of sucralose claim that it is unable to be metabolized, up to 35% is absorbed by the body with a half life up to 23 hours.

2. Pre-approval tests indicated potential toxicity for sucralose. One study (printed in the “New Scientist”, 23 November 1991, volume 132, page 13) demonstrated that thymus weight decreased by up to 40% in rats fed diets rich in sucralose, indicating that sucralose has the potential to compromise the immune system. Note that the FDA also addressed this (and other) toxicity concerns in their Final Rule, claiming that these negative effects would not be seen in humans at recommended doses.

3. Sucralose is a chlorinated compound. Other classes of chlorinated molecules include pesticides.

4. There are no independent controlled human studies on sucralose. The bulk of the safety research has been conducted by the manufacturer.

5. There are no long-term (>13 months) human studies of sucralose’s effects and no long history of use.